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Under hypoxic conditions, Ras-driven gliomas cells can uptake FAs from the exterior to promote cell proliferation and maintain membrane integrity [131]

Besides reduced drug accumulation, cisplatin resistance develops through an increased ability to avoid drug-induced cell damage, cell shrinkage and, therefore, initiation of apoptosis (40)

Ravindra M, Wallace-Povirk A, Karim MA, Wilson MR, O'Connor C, White K, et al

[DOI] [PubMed] [Google Scholar] 184.Lewin TM, Kim JH, Granger DA, Vance JE, Coleman RA

doi: 10.21037/atm-22-5196 137 MekhailMAlmazanGTabrizianM

That three-receptor approach is what separates it from Tirzepatide (dual agonist) and Semaglutide (single agonist), and the clinical data reflects that gap clearly